Journal
FOOD & FUNCTION
Volume 11, Issue 1, Pages 596-605Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9fo02202c
Keywords
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Funding
- Pearl River S&T Nova Program of Guangzhou [201806010169]
- National Natural Science Foundation of China [81773592]
- Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme
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Durian, known as the king of fruits, is rich in nutrients and bioactive phytochemicals. Propacin is a bioactive coumarinolignoid isolated from durian. In this study, we demonstrated its anti-inflammatory effect on lipopolysaccharide (LPS)-induced RAW264.7 cells and explored the underlying mechanism. Propacin suppressed nitric oxide (NO) and prostaglandin E2 (PGE(2)) production in LPS-stimulated macrophages significantly by downregulating the mRNA and protein expression of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Moreover, propacin decreased the overexpression of the LPS-induced reactive oxygen species (ROS) and maintained the mitochondrial integrity in active macrophages. Furthermore, propacin inhibited the translocation of the nuclear factor-kappa B (NF-kappa B) p65 subunit into the nucleus and the phosphorylation of mitogen-activated protein kinases (MAPKs), especially JNK and ERK. Collectively, these data indicated that propacin may have the potential to be developed as a novel therapeutic agent for inflammatory-related diseases.
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