Journal
JOURNAL OF CLINICAL LABORATORY ANALYSIS
Volume 32, Issue 2, Pages -Publisher
WILEY
DOI: 10.1002/jcla.22228
Keywords
reference interval; the lymphocyte-to-monocyte ratio; the monocyte-to-lymphocyte ratio; the neutrophil-to-lymphocyte ratio; the platelet-to-lymphocyte ratio; the systemic immune-inflammation index
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Funding
- Key Project on Science and Technology Research, Henan Province, China [152102410067, 162102310142, 201403035]
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ObjectivesBy now, there are few data of the reference intervals (RIs) of SII, PLR, NLR, LMR and MLR. We aimed to establish RIs of SII, PLR, NLR, LMR and MLR for healthy persons. MethodsA retrospective analysis on a cohort of ostensibly healthy, aged no <18years old physical examinees who took health examination from January to December in 2013 was conducted to explore influences of age and gender on SII, PLR, NLR, LMR and MLR and to establish their RIs. And another cohort of 450 persons in our hospital from January to July in 2016 is included for validations of RIs. ResultsNLR, LMR and MLR were significantly different between gender groups (P=.010; P<.001; P<.001, separately), while SII and PLR were not (P=.137; P=.267, separately). While SII was not changed much between age groups (P=.842), PLR, NLR, LMR and MLR were significantly different (all with P<.001). RIs of SII, PLR, NLR, LMR and MLR were: SII: [161,701]; PLR: 18-65year-old: [61,179]/>65year-old: [55,179]; NLR: 18-65year-old male: [0.90,2.94]/18-65year-old female: [0.85,3.06]/>65year-old male: [0.95,3.57]/aged >65year-old female: [0.83,3.30]; LMR: 18-65year-old male: [2.50,7.50]/18-65year-old female: [2.75,8.50]/>65year-old male: [2.16,7.41]/>65year-old female: [2.40,8.33]; MLR: 18-65year-old male: [0.12,0.35]/18-65year-old female: [0.10,0.32]/>65year-old male: [0.12,0.41]/>65year-old male: [0.11,0.33]. ConclusionsRIs of SII, PLR, NLR, LMR and MLR of people in central China were established and validated. It will benefit experimental design of the related studies and lead to better standardizations of SII, PLR, NLR, LMR and MLR for their clinical applications.
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