Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 127, Issue 2, Pages 450-453Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI91880
Keywords
-
Categories
Funding
- NIH [R01 AA023416, DK082724]
- American Diabetes Association
Ask authors/readers for more resources
Insulin replacement is the cornerstone of type 1 diabetes (T1D) treatment; however, glycemic control remains a challenge. Leptin has been shown to effectively restore euglycemia in rodent models of T1D; however, the mechanism or mechanisms by which leptin exerts glycemic control are unclear. In this issue of the JCI, Perry and colleagues provide evidence that suppression of lipolysis is a key facet of leptin-mediated restoration of euglycemia. However, more work remains to be done to fully understand the antidiabetic mechanisms of leptin.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available