Journal
JOURNAL OF CLINICAL IMMUNOLOGY
Volume 37, Issue 5, Pages 486-495Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10875-017-0405-7
Keywords
Ataxia telangiectasia; Chronic mucocutaneous candidiasis disease; Flow cytometry; Hyper IgE syndrome; Primary immunodeficiency disease
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Ministry of Health, Labour, and Welfare of Japan
- Grants-in-Aid for Scientific Research [15K09640] Funding Source: KAKEN
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Primary immunodeficiency diseases (PIDDs) are rare inherited diseases that impair the human immune system. We established a multicolor flow cytometric assay to comprehensively evaluate the immune status and immunological characteristics of patients with PIDDs. Fifty-nine normal controls and 75 patients with PIDDs, including X-linked severe combined immunodeficiency (X-SCID), X-linked agammaglobulinemia (XLA), X-linked hyper IgM syndrome (X-HIGM), ataxia telangiectasia (AT), Wiskott-Aldrich syndrome (WAS), hyper IgE syndrome (HIES), and chronic mucocutaneous candidiasis disease (CMCD), were enrolled in this study. Immunophenotyes were evaluated by multicolor flow cytometry using seven different panels that allowed the detection of major leukocyte populations in peripheral blood. Multicolor flow cytometry revealed distinct leukocyte populations and immunological features of patients with X-SCID, XLA, X-HIGM, AT, WAS, HIES, and CMCD. Immunophenotyping by multicolor flow cytometry is useful to evaluate immune status and contributes to the diagnosis and management of patients with PIDDs.
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