Journal
JOURNAL OF CLINICAL HYPERTENSION
Volume 20, Issue 1, Pages 4-10Publisher
WILEY
DOI: 10.1111/jch.13138
Keywords
carotid intima-media thickness; carotid plaque; general population; metabolic syndrome
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We performed a meta-analysis of population studies reporting data on carotid intima-media thickness and plaque in patients with and without metabolic syndrome (MetS) to provide a new piece of information on the relationship of MetS with both phenotypes of vascular damage. The Ovid MEDLINE, PubMed, and Cochrane CENTRAL databases were searched without time restriction up to December 31, 2016. Overall, 19696 patients (22.2% with MetS) were included in eight studies. Common carotid intima-media thickness was greater in patients with MetS compared with those without it (788 +/- 47m vs 727 +/- 44m), with a standard means difference of 0.28 +/- 0.06 (P=.00003). Increased intima-media thickness in patients with MetS was paralleled by a higher prevalence of plaques. The present meta-analysis shows that MetS is associated with both ultrasonographic phenotypes of carotid damage. This finding is consistent with the view of MetS as a cluster of hemodynamic and nonhemodynamic factors promoting vascular hypertrophy and plaque.
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