Journal
JOURNAL OF CLINICAL HYPERTENSION
Volume 19, Issue 9, Pages 833-839Publisher
WILEY
DOI: 10.1111/jch.13007
Keywords
anxiety; depression; EQ-5D; quality of life; renal sympathetic denervation
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Funding
- Medtronic, Global SYMPLICITY Registry [NCT01534299]
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Renal denervation has been shown to reduce blood pressure in patients with uncontrolled hypertension, but less is known about its impact on quality of life. This analysis evaluated 12-month blood pressure and quality of life outcomes in 934 patients from the Global SYMPLICITY Registry who completed the EuroQoL five-dimensions three-level questionnaire (EQ-5D-3L). At baseline, 32% of patients reported anxiety/depression and 48% reported pain/discomfort. At 12months (n=496), office and 24-hour ambulatory systolic blood pressure were reduced by 13.9 +/- 26.6 and 7.7 +/- 19.3mmHg, respectively, and 8% (P<.001) more patients reported no problems in anxiety/depression. Furthermore, numerically more patients reported no problems in pain/discomfort (4%, P=.08). Perceived health-related quality of life (visual analog scale) improved from baseline to 12months (68 +/- 18 vs 73 +/- 17, P<.001), and the improvement was largest among patients with severe anxiety/depression at baseline (50 +/- 24 vs 64 +/- 22, P=.005 [n=32]). In this analysis, renal denervation was associated with a significant improvement in health-related quality of life, particularly anxiety/depression.
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