Journal
RSC ADVANCES
Volume 10, Issue 5, Pages 2870-2876Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ra09531d
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Funding
- Joint Fund of the National Natural Science Foundation of China and Henan province [U1804198]
- National Natural Science Foundation of China [31700820]
- Key Scientific Research Projects of higher education institutions in Henan province [18A180003]
- Joint Fund for Fostering Talents of NCIR-MMT HNKL-MMT [MMT2017-04]
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Recently, in situ formed injectable hydrogels have shown great potential in biomedical applications as therapeutic implants or carriers in tissue repair and regeneration. They can seal or fill the damaged tissue to function as cell/drug delivery vehicle perfectly through a minimally invasive surgical procedure. In this study, hyaluronic acid (HA) is functionalized with tyramine to produce an injectable hydrogel dual-enzymatically crosslinked by horseradish peroxidase (HRP) and galactose oxidase (GalOX). This new tyramine-modified HA (HT) hydrogel exhibited good injectability, favorable cytocompatibility to mice bone marrow mesenchymal stem cells (BMSCs), and low inflammatory response verified by cytotoxicity assay in vitro and an in situ subcutaneous injection study in vivo. In addition, the gelation time, swelling behavior, and degradation rate of the HT hydrogel could be adjusted through varying the concentrations of HT and GalOX in a certain range. These encouraging results suggest that such biocompatible HT hydrogels might have potential application in three-dimensional stem cell culture and tissue engineering.
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