Journal
INSIGHTS INTO IMAGING
Volume 11, Issue 1, Pages -Publisher
SPRINGER
DOI: 10.1186/s13244-019-0795-6
Keywords
Radiomics; Radiogenomics; Molecular profiling; Precision medicine
Funding
- NIH/NCI Cancer Center Support Grant [P30 CA008748]
- Breast Cancer Research Foundation
- Susan G. Komen
- Spanish Foundation Alfonso Martin Escudero
- European School of Radiology
- Jubilaumsfonds of the Austrian National Bank
- 2020 Research and Innovation Framework Programme PHC-11-2015 [667211-2]
- H2020-FETOPEN-2018-2019-2020-01 [828978]
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Background Radiogenomics is the extension of radiomics through the combination of genetic and radiomic data. Because genetic testing remains expensive, invasive, and time-consuming, and thus unavailable for all patients, radiogenomics may play an important role in providing accurate imaging surrogates which are correlated with genetic expression, thereby serving as a substitute for genetic testing. Main body In this article, we define the meaning of radiogenomics and the difference between radiomics and radiogenomics. We provide an up-to-date review of the radiomics and radiogenomics literature in oncology, focusing on breast, brain, gynecological, liver, kidney, prostate and lung malignancies. We also discuss the current challenges to radiogenomics analysis. Conclusion Radiomics and radiogenomics are promising to increase precision in diagnosis, assessment of prognosis, and prediction of treatment response, providing valuable information for patient care throughout the course of the disease, given that this information is easily obtainable with imaging. Larger prospective studies and standardization will be needed to define relevant imaging biomarkers before they can be implemented into the clinical workflow.
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