Journal
BIOMEDICINES
Volume 8, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines8010009
Keywords
rheumatoid arthritis; gene therapy; AAV; miRNA; siRNA; lncRNA; circRNA; monoclonal antibodies; gene delivery; CIA; clinical trials
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Funding
- Ministry of Science and Higher Education of the Russian Federation [RFMEFI60518X0003]
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Rheumatoid arthritis (RA) is a systemic inflammatory joint disease affecting about 1% of the population worldwide. Current treatment approaches do not ensure a cure for every patient. Moreover, classical regimens are based on nontargeted systemic immune suppression and have significant side effects. Biological treatment has advanced considerably but efficacy and specificity issues remain. Gene therapy is one of the potential future directions for RA therapy, which is rapidly developing. Several gene therapy trials done so far have been of moderate success, but experimental and genetics studies have yielded novel targets. As a result, the arsenal of gene therapy tools keeps growing. Currently, both viral and nonviral delivery systems are used for RA therapy. Herein, we review recent approaches for RA gene therapy.
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