Journal
DENTAL MATERIALS JOURNAL
Volume 34, Issue 1, Pages 108-113Publisher
JAPANESE SOC DENTAL MATERIALS DEVICES
DOI: 10.4012/dmj.2014-175
Keywords
Gallic acid; Mineralization regulation; Hydroxyapatite crystal
Funding
- State Key Laboratory of Oral disease, Sichuan University
- National Natural Science Foundation of China [81170958, 51073102]
- State Key Laboratory of Oral Diseases [SKLODSCU20120059]
- Sichuan Province applied basic research program [2010JY0056]
- Sichuan Province Science and technology support program [2011SZ0130]
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The purpose of this study is to detect the effect of gallic acid (GA) on hydroxyapatie crystal growth and find the mechanism of the regulation. We evaluated the morphology of HAP crystals grown under various amounts of GA (0, 0.05, 1, and 4 gL(-1)). Subsequently, the chemical composition, crystal size and the morphology were investigated via the energy-dispersive X-ray spectrometer, attenuated total fourier transform infrared spectroscopy, thermogravimetric analysis, X-ray diffraction analysis, transmission electron microscope and scanning electron microscopy. In all groups, the Ca/P ratio was closed to 1.67. In the absence of GA, crystals did not arrange, while in the presence of GA, crystals tended to form spherules. The size of the crystals decreased with the concentration of GA increased. These results indicated the role of GA on the growth and morphology of hydroxy-apatite crystals, which might be the key mechanism for gallic acid regulating the mineralization.
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