Journal
JOURNAL OF BIOMEDICAL SCIENCE
Volume 27, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12929-019-0591-0
Keywords
Carbohydrates; Immunogenicity; Antigenicity; Polysaccharides; Vaccines and Cancer
Categories
Funding
- Academia Sinica [AS-SUMMIT-108]
- Ministry of Science and Technology [MOST 108-3114-Y-001-002, MOST 107-0210-01-19-01]
Ask authors/readers for more resources
Glycoconjugate vaccines based on bacterial capsular polysaccharides (CPS) have been extremely successful in preventing bacterial infections. The glycan antigens for the preparation of CPS based glycoconjugate vaccines are mainly obtained from bacterial fermentation, the quality and length of glycans are always inconsistent. Such kind of situation make the CMC of glycoconjugate vaccines are difficult to well control. Thanks to the advantage of synthetic methods for carbohydrates syntheses. The well controlled glycan antigens are more easily to obtain, and them are conjugated to carrier protein to from the so-call homogeneous fully synthetic glycoconjugate vaccines. Several fully glycoconjugate vaccines are in different phases of clinical trial for bacteria or cancers. The review will introduce the recent development of fully synthetic glycoconjugate vaccine.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available