Journal
JOURNAL OF BIOMEDICAL SCIENCE
Volume 27, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12929-019-0610-1
Keywords
Siglec-15; Sialic acid; Osteoclast; Macrophage; Cancer; Microbial infection
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Funding
- Ministry of Science and Technology, Taiwan [MOST 107-2311-B-001-034]
- Academia Sinica, Taiwan [AS-SUMMIT-108]
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Siglec-15 is a member of the Siglec family of glycan-recognition proteins, primarily expressed on a subset of myeloid cells. Siglec-15 has been known to be involved in osteoclast differentiation, and is considered to be a potential therapeutic target for osteoporosis. Recent studies revealed unexpected roles of Siglec-15 in microbial infection and the cancer microenvironment, expanding the potential pathophysiological roles of Siglec-15. Chemical biology has advanced our understanding of the nature of Siglec-15 ligands, but the exact nature of Siglec-15 ligand depends on the biological context, leaving plenty of room for further exploration.
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