Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
Volume 16, Issue 6, Pages 957-969Publisher
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.38264
Keywords
innate lymphoid cell; pregnancy; trophoblast invasion; spiral artery remodeling; reproductive failure; preeclampsia
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Funding
- National Key Research and Development Program of China [2017YFC1001404]
- National Natural Science Foundation of China (NSFC) [31671200, 31970798, 81901563, 91542108, 81471513, 81471548]
- NPFPC Key Laboratory of Reproduction Regulation [CX2017-2]
- Program for Zhuoxue of Fudan University
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Pregnancy constitutes a major challenge to the maternal immune system, which must tolerate fetal alloantigen encoded by paternal genes. In addition to their role in inducing maternal-fetal immune tolerance, accumulating evidence indicates that decidual immune cells are involved in several processes required for a successful pregnancy, including trophoblast invasion as well as tissue and spiral artery remodeling. Innate lymphoid cells (ILCs), an important branch of the innate immune system, which has expanded rapidly in recent years, are strong actors in mucosal immunity, tissue homeostasis and metabolism regulation. With the recent identification of ILCs in the human decidua, the role of ILCs at the maternal-fetal interface raises concern. Herein, we review the presence and characterization of ILCs in the human decidua, as well as their function in normal pregnancy and pathological pregnancy, including reproductive failure, preeclampsia and others.
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