Journal
JOURNAL OF CHEMICAL SCIENCES
Volume 132, Issue 1, Pages -Publisher
INDIAN ACAD SCIENCES
DOI: 10.1007/s12039-020-1745-z
Keywords
Reversible and selective detection of Zn2+; Fe2+ as the reversible switch; pH and temperature dependence; DFT and TD-DFT; On-site screening analysis; Cellular imaging
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Funding
- Science and Engineering Research Board, Government of India, New Delhi [ECR-2016-000839/CS]
- Board of Research in Nuclear Science (BRNS), Mumbai [37(2)/14/18/2017-BRNS]
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Temperature-driven, highly sensitive and selective TURN-ON fluorometric detection of Zn2+ by benzothiazole-based probes (L-1 and L-2) was reported in physiological pH in the present work. Iron(II) acted as the reversible switch or trigger for the reversible detection of Zn2+ ions by the probes resulting in TURN-OFF fluorescence at room temperature. However, selective detection of Zn2+ in the presence of Fe2+ was irreversible at 0-5 degrees C. Such temperature dependence on reversible fluorometric detection of Zn2+ in the presence of Fe2+ was explained from the thermodynamic perspective as well as DFT calculations in which the absolute enthalpy (H) and Gibbs free energy (G) of the resultant complexes and the fluorophores (L-1 and L-2) at different temperatures were determined. Enhanced fluorescence of the Zn2+ bound probes was due to the inhibition of excited-state intramolecular proton transfer (ESIPT). Effect of solvents, pH, and temperature on the fluorometric detection of Zn2+ was also probed in the present work. The results were translated into the visual detection of Zn2+ on paper-based fluorescence probe and later we demonstrated the sensing of mobile Zn2+ ions by the probes in living HeLa cells as the proof of concept of our present investigations.
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