Journal
JOURNAL OF CANCER
Volume 11, Issue 8, Pages 2000-2007Publisher
IVYSPRING INT PUBL
DOI: 10.7150/jca.40531
Keywords
FGF/FGFR; resistance; oncotherapy; FGF/FGFR inhibitors
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Funding
- Wenzhou Science & Technology Bureau Project [Y20180075, Y20190070]
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Resistance becomes major clinical issue in cancer treatment, which strongly limits patients to benefit from oncotherapy. Growing evidences have been indicative of the critical role of fibroblast growth factor (FGF)/receptor (FGFR) signaling played in resistance to oncotherapy. In this review we dicussed the underlying mechanisms of FGF/FGFR signaling mediated resistance to chemotherapy, radiotherapy and target therapy in various cancers. Meanwhile, we summarized the reported mechanism of FGF/FGFR inhibitors resistance in cancers.
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