Journal
CHEMICAL SCIENCE
Volume 11, Issue 8, Pages 2045-2050Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9sc05510j
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Funding
- National Science Foundation [CAREER DMR-1654405]
- Welch Foundation [AT-198920190330, AT-1877-20180324]
- National Science Foundation Graduate Research Fellows Program [1746053]
- University of Texas at Dallas Office of Research through the COBRA program
- Direct For Education and Human Resources
- Division Of Graduate Education [1746053] Funding Source: National Science Foundation
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Many contrast agents for magnetic resonance imaging are based on gadolinium, however side effects limit their use in some patients. Organic radical contrast agents (ORCAs) are potential alternatives, but are reduced rapidly in physiological conditions and have low relaxivities as single molecule contrast agents. Herein, we use a supramolecular strategy where cucurbit[8]uril binds with nanomolar affinities to ORCAs and protects them against biological reductants to create a stable radical in vivo. We further overcame the weak contrast by conjugating this complex on the surface of a self-assembled biomacromolecule derived from the tobacco mosaic virus.
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