Journal
NANOSCALE
Volume 12, Issue 8, Pages 4839-4845Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9nr08127e
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Funding
- IMDEA Energy
- Spanish Ramon y Cajal Programme [2014-16823]
- Talento Mod. 2 fellowship from Madrid Community [2018-T2/IND-11407]
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Despite the great interest in RNA therapeutics, the development of a successful gene delivery process is still a major challenge. We propose an efficient nucleic acid entrapment into the mesopores of biocompatible nanoscaled metal-organic frameworks. Their rapid cellular uptake together with RNA protection and release led to a relevant in vitro gene activity.
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