Journal
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Volume 1060, Issue -, Pages 355-366Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jchromb.2017.06.032
Keywords
Anemarrhena asphodeloides Bge; Cyclic peptides; Xanthones; Steroidal saponins; UHPLC-QTOF-MS
Funding
- National Natural Science Foundation of China [81303223]
- Specialized Research Fund for the Doctoral Program of Higher Education [20133237120007]
- Natural Science Research Project of Jiangsu Higher Education Institution [13KJB360012]
- ational Basic Special Project of Science and Technology [2014FY111100]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
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The rhizome of Anemarrhena asphodeloides Bge. is commonly used as an herbal medicine in China. In this study, ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS) was used, in both negative and positive ion modes, to comprehensively analyze the chemical constituents of A. asphodeloides. From the intact precursor ions, MS/MS fragmentation information, and previous reports, we identified 89 compounds. These compounds included 8 cyclic peptides, 11 flavones (9 xanthones), 45 steroidal saponins, 15 fatty acids, 3 lignans, and 7 other compounds. Dimer xanthones and cyclic peptides are reported for the first time in A. asphodeloides. The analytical method we have developed is simple, reliable, and effective. The results provide comprehensive information on the metabolite profile of A. asphodeloides, which may benefit the quality control and further utilization of A. asphodeloides.
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