Journal
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Volume 1048, Issue -, Pages 102-110Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jchromb.2017.02.016
Keywords
Molecularly imprinted; Monolithic; Pipette-tip solid phase microextraction; Gallic acid; Experimental design; HPLC-UV
Funding
- Graduate School of Yasouj University
- Research Council of Yasouj University
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A novel strategy was presented for the synthesis and application of functionalized silica monolithic as artificial receptor of gallic acid at micro-pipette tip. A sol-gel process was used to prepare the sorbent. In this in-situ polymerization reaction, tetraethyl orthosilicate (TEOS), 3-aminopropyl trimethoxysilane (APTMS), gallic acid and thiourea were used, respectively, as cross-linker, functionalized monomer, template and precursor to make crack-free and non-fragile structure. Such durable and inexpensive in-situ monolithic was successfully employed as useful tool for highly efficient extraction of gallic acid from orange juice samples. The effective parameters in extraction recovery were investigated and optimum conditions were obtained using experimental design methodology. Applying HPLC-UV for separation quantification at optimal conditions, the gallic acid was efficiently extracted without significant matrix interference. Good linearity for gallic acid in the range of 0.02-5.0 mg L-1 with correlation coefficients of R-2 > 0.999 revealed well applicability of the method for trace analysis. (C) 2017 Published by Elsevier B.V.
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