Journal
PHYSICAL REVIEW E
Volume 101, Issue 3, Pages -Publisher
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevE.101.032602
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Funding
- Netherlands Organization for Scientific Research (NWO/OCW), Frontiers of Nanoscience program
- Netherlands Organization for Scientific Research (NWO-ENW) within the Innovational Research Incentives Scheme [865.17.004]
- Leiden/Huygens fellowship
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Recent experimental studies have demonstrated that cellular motion can be directed by topographical gradients, such as those resulting from spatial variations in the features of a micropatterned substrate. This phenomenon, known as topotaxis, has been extensively studied for topographical gradients at the subcellular scale, but can also occur in the presence of a spatially varying density of cell-sized features. Such a large-scale topotaxis has recently been observed in highly motile cells that persistently crawl within an array of obstacles with smoothly varying lattice spacing. We introduce a toy model of large-scale topotaxis, based on active Brownian particles. Using numerical simulations and analytical arguments, we demonstrate that topographical gradients introduce a spatial modulation of the particles' persistence, leading to directed motion toward regions of higher persistence. Our results demonstrate that persistent motion alone is sufficient to drive large-scale topotaxis and could serve as a starting point for more detailed studies on self-propelled particles and cells.
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