Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1505, Issue -, Pages 77-86Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2017.04.062
Keywords
Human scent analysis; Molecular composition of human scent; Forensic chemistry; Human scent signature; GCxGC-TOFMS
Funding
- Ministry of the Interior of the Czech Republic [Vf 20142015036, VI20172020075]
- Institute of Organic Chemistry and Biochemistry of the CAS [61388963]
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Instrumental human scent analysis is undoubtedly desirable for many forensic as well medical applications. Most of the previous human scent studies were focused on volatile organic compounds (VOCs) which were analysed by head space solid phase micro-extraction gas chromatography/mass spectrometry (HS-SPME-GC/MS). This method is, however, significantly less sensitive to heavier less volatile compounds emitted from the human skin. These less volatile organic scent molecules probably create the basis of the individual human scent signature, and therefore, our attention is focused mainly on these heavier compounds. The human scent was adsorbed onto purified glass beads and samples were prepared as hexane solutions obtained by extraction from the sampled glass beads. To resolve a lot of very similar molecules, the comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometer (GCxGC-TOFMS) was used to analyse the hexane scent solutions. Using this technique, more than 137 less volatile molecules including organic fatty acids, ketones, aldehydes, simple esters, alcohols, and especially various fatty acid esters with different carbon chains were identified. A considerable number of these molecules were identified in the scent samples for the first time. (C) 2017 Elsevier B.V. All rights reserved.
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