Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1483, Issue -, Pages 86-92Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2016.12.064
Keywords
Enantioseparations; Chiral HPLC; Polysaccharide-based chiral stationary phases; Reversal of enantiomer elution order
Funding
- Shota Rustaveli National Science Foundation (RNSF) of Georgia [31/90]
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When polysaccharide-based chiral columns are used in combination with aqueous-organic mobile phases for the separation of enantiomers in high-performance liquid chromatography the separation mode is commonly called reversed-phase in analogy to achiral separations. In several earlier and recent studies on neutral and basic chiral analytes it was shown by our and other groups that due to multiple type of interactions involved in selector-selectand binding and enantioselective recognition with polysaccharide derivatives, the above mentioned separation system may not always behave like a reversed-phase system. In the present study additional examples of non-reversed-phase behavior are described for the first time for weak acidic chiral analytes. In addition, the reversal of enantiomer elution order was observed again for the first time for several analytes based on water-content in the mobile phase. (C) 2016 Elsevier B.V. All rights reserved.
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