Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1524, Issue -, Pages 49-56Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2017.09.074
Keywords
Porosity; Cyclodextrin polymer; Solid-phase extractant; Antiepileptic drugs; HPLC-DAD
Funding
- Research Project of Environment Protection Department of Jiangsu Province [2015026]
- Joint Capital Project of Science and Technology Department of Guizhou Province [LH [2016] 7076]
- Open Project of Key Laboratory of Biomedical Functional Materials of China Pharmaceutical University
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In this study, a novel solid phase extraction based on porous magnetic graphene oxide-cyclodextrin polymers (MGO-CD) was developed with aromatic linker and used for the simultaneous extraction and preconcentration of trace antiepileptic drugs in plasma. The characteristics of MGO-CD were assessed by Fourier transform infrared spectroscopy (FT-IR), Brunauer-Emmett-Teller surface areas (BET), Transmission Electron Microscope (TEM), Scanning Electron Microscope (SEM), X-ray diffraction (XRD) and vibrating sample magnetometer (VSM). Magnetic cyclodextrin polymeric material exhibited a high specific surface area (187 m(2) g(-1)), large pore volume (0.12 cm(3) g(-1)), good saturated magnetization (37.68 emu g(-1)), and excellent dispersibility in aqueous solution. Various parameters influencing the extraction recovery of drugs were studied. The method exhibited good linearity in the range of 1-50 pgmL-1, and the limit of quantitation of carbamazepine, phenytoin, diazepam was 11.89, 47.10 and 16.17 ngmL(-1), respectively. The recoveries of three antiepileptic drugs range from 78.49 to 100.93% with relative standard deviations less than 5.5%. These analytical results demonstrated that the proposed approach based on MGO-CD was applicable for analysis of antiepileptic drugs in plasma samples. (C) 2017 Elsevier B.V. All rights reserved.
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