Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1499, Issue -, Pages 211-216Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2017.04.002
Keywords
Ultrafast chiral separations; Enantiopurity analysis; High throughput analysis; High speed autosampler; Multiple injections in a single experimental; run
Funding
- MRL Postdoctoral Research Fellows program
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The combination of high speed autosampler technology and ultrafast chromatographic separations enables faster high throughput analysis. With an injection cycle time of 10.6 s, MISER (Multiple Injection in a Single Experimental Run) HPLC-MS analysis of a 96 well microplate can be completed in only 17 min. As chromatographic separations in the sub 5 s range become increasingly common, even faster autosamplers will be needed to realize further speed improvements in high throughput LC-MS analysis. Indeed with proper hardware sampling approaches, chromatographic analysis of microplates could approach speeds of spectrophotometric plate readers while maintaining the advantage of multicomponent detection and monitoring. (C) 2017 Elsevier B.V. All rights reserved.
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