Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1516, Issue -, Pages 64-70Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2017.07.095
Keywords
Gradient; Linear solvation energy relationships (LSERs); Normal phase liquid chromatography; DNAP
Funding
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- University of Alberta
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Coupling the modified Soczewifiski model and one gradient run, a gradient method was developed to build a linear solvation energy relationship (LSER) for normal phase chromatography. The gradient method was tested on dinitroanilinopropyl (DNAP) and silica columns with hexaneiclichloromethane (DCM) mobile phases. LSER models built based on the gradient separation agree with those derived from a series of isocratic separations. Both models have similar LSER coefficients and comparable goodness of fit, but the LSER model based on gradient separation required fewer trial and error experiments. (C) 2017 Elsevier B.V. All rights reserved.
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