Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1490, Issue -, Pages 63-73Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2017.02.018
Keywords
Amlodipine; Enantioseparation; Hollow fiber; Molecularly imprinted membrane; Triple recognition
Funding
- National Natural Science Foundation of China [21505112, 21305118]
- Hunan Provincial Science and Technology Department [2013SK2021]
- Education Department of Hunan Province [14C1087]
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In this study, a triple recognition chiral extraction process has been developed to separate (S)-amlodipine from racemic raw medicine, based on the combination of molecularly imprinted hollow fiber membrane and cross-flow biphasic recognition extraction. The chiral separation process was operated in a dismountable hollow fiber module coated with molecularly imprinted polymer, and the cross-flow extraction was applied with D-tartaric acid in feed phase and sulfobutyl ether-beta-cyclodextrin in stripping phase. The synergistic effect of molecularly imprinted polymer and dual chiral additives was investigated, and excellent enantioseparation ability with a selectivity factor of 1.98 was obtained. Mathematical model of S/R = 0.598e(0:50NTU) for racemic amlodipine separation by molecularly imprinted hollow fiber membrane extraction was established. The optical purity for amlodipine is up to 90% when 4 hollow fiber membrane modules of 25 cm in length in series are used. The triple recognition process strongly enhanced the separation selectivity; therefore it may bring about the potentially application for large-scale production of pure enantiomeric compound. (C) 2017 Elsevier B.V. All rights reserved.
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