Journal
CHEMICAL SCIENCE
Volume 11, Issue 6, Pages 1623-1628Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9sc04029c
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Funding
- [NSFC-21772218]
- [21821002]
- [XDB20000000]
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A copper-catalyzed enantioselective arylalkynylation of alkenes with diaryliodonium salt and a monosubstituted alkyne is reported. The three-component coupling reactions proceed under mild reaction conditions with a broad substrate scope, leading to synthetically valuable 1,2-diaryl-3-butynes. The key to the success of this chemistry is the employment of the chiral bisoxazoline-phenylaniline (BOPA) ligand. A novel reaction pathway involving the phenyl radical generation under thermal copper catalysis is proposed according to mechanistic studies.
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