Journal
TRENDS IN CANCER
Volume 6, Issue 2, Pages 160-171Publisher
CELL PRESS
DOI: 10.1016/j.trecan.2019.12.001
Keywords
-
Categories
Funding
- South-Eastern Norway Regional Health Authority
- Norwegian Cancer Society
Ask authors/readers for more resources
Cancer cells exploit many of the cellular adaptive responses to support their survival needs. One of these is the unfolded protein response (UPR), a highly conserved signaling pathway that is mounted in response to endoplasmic reticulum (ER) stress. Recent work showed that steroid hormones, in particular estrogens and androgens, regulate the canonical UPR pathways in breast cancer (BCa) and prostate cancer (PCa). In addition, UPR has pleiotropic effects in advanced disease and development of therapy resistance. These findings implicate the UPR pathway as a novel target in hormonally regulated cancers in the clinic. Here, we review the potential therapeutic value of recently developed small molecule inhibitors of UPR in hormone regulated cancers.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available