Journal
CHEMICAL COMMUNICATIONS
Volume 56, Issue 12, Pages 1859-1862Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc09640j
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Funding
- National Natural Science Foundation of China [21871003, 51672002, 21701160, 21602003, 51432001, 51772002]
- Anhui University [S020118002/073, S020118002/026]
- Nature Science Foundation of Anhui Province [1708085MC68, 1908085MB30]
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We present the design and synthesis of water-soluble quinoline-indole-based derivatives (IM-1, IM-2, and IM-3) with three-photon absorption activity. IM-3 can specifically target DNA and RNA accompanied by an obvious three-photon fluorescence enhancement in the second near-infrared window (1000-1700 nm). The in vitro experiments demonstrate that IM-3 can simultaneously stain mitochondria and the nucleolus both in living and fixed cells. The organelle-specific targeting behaviour is successfully visualized under stimulated emission depletion (STED) nanoscopy.
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