Journal
CHEMICAL COMMUNICATIONS
Volume 56, Issue 19, Pages 2857-2860Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc09841k
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Funding
- National Natural Science Foundation of China [21778028, 21572093]
- Ministry of Science and Technology National Key RD Project [2018YFE0205100]
- Natural Science Foundation of Gansu Province [18JR4RA003]
- 111 project
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The first beta-allyl carbamate fluorescent probe, AC-green, was reported for specifically imaging vicinal dithiol proteins (VDPs) in living systems. The probe displays low toxicity and features high sensitivity and fast response towards VDPs. A drastic loss of VDPs in a Parkinson's model was disclosed by AC-green, linking the fluctuation of VDP levels to Parkinson's disease for the first time. The structural novelty and favorable properties of AC-green will advance the development of novel VDP probes.
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