Journal
CHEMICAL SCIENCE
Volume 11, Issue 5, Pages 1368-1374Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9sc05558d
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Funding
- MSCA Individual Fellowship [659046]
- Fundacion Antonio Martin Escudero (FAME)
- CRUK Career Development Fellowship [C49791/A17367]
- ERC [716379, 771443]
- Ministerio de Econom'ia y Competitividad-Spain [CTQ2015-67870-P, ERA-NET PCIN-2015-224]
- Generalitat de Catalunya [2017 SGR 1439]
- Wellcome Trust iTPA [PIII-006]
- OPTIMA [EP/L016559/1]
- [EP/M507258/1]
- European Research Council (ERC) [771443, 716379] Funding Source: European Research Council (ERC)
- EPSRC [EP/M507258/1] Funding Source: UKRI
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Keratin 1 (KRT1) is overexpressed in squamous carcinomas and associated with aggressive pathologies in breast cancer. Herein we report the design and preparation of the first Trp-based red fluorogenic amino acid, which is synthetically accessible in a few steps and displays excellent photophysical properties, and its application in a minimally-disruptive labelling strategy to prepare a new fluorogenic cyclopeptide for imaging of KRT1+ cells in whole intact tumour tissues.
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