Journal
JOURNAL OF CHEMICAL NEUROANATOMY
Volume 95, Issue -, Pages 95-114Publisher
ELSEVIER
DOI: 10.1016/j.jchemneu.2017.11.008
Keywords
Aging; Calcium signaling; Neuronal calcium homeostasis; Calcium channels; Aging associated neurodegenerative disease; Oxidative stress; Excitotoxicity
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Funding
- Rajiv Gandhi Centre for Biotechnology (RGCB), Government of India (GOI)
- Indian Council of Medical Research (ICMR), GOI
- ICMR
- Kerala State Council for Science, Technology and Environment (KSCSTE), Government of Kerala, India
- Council of Scientific and Industrial Research (CSIR), GOI
- Department of Science and Technology (DST), GOI
- Department of Biotechnology (DBT), GOI
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Aging in the biological system is an irreversible process. In the initial stages of lifespan aging improves survival skills of an organism while in the later stages aging reduce the survival skills. Aging is associated with changes in several cellular and molecular functions among which calcium signaling is a prominent one. Calcium signaling is essential for many vital functions of the brain and even minor impairments in calcium signaling can lead to deleterious consequences including neuronal death. Calcium signaling proteins are pursued as promising drug targets for many aging related diseases. This review attempts to summarize changes in calcium signaling in the brain as a result of aging.
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