Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 8, Issue 7, Pages 1432-1444Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9tb02212k
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Funding
- project of High-level Teachers in Beijing Municipal Universities in the Period of 13th Five-year Plan [CITTCD201804025]
- Beijing Municipal Education Commission [KM201910011009]
- Construction of Scientific and Technological Innovation and Service Capability-Basic Scientific Research Funding Project [PXM2018_014213_000033]
- National Natural Science Foundation of China [21401008]
- Graduate Student Scientific Research Ability Promotion of BTBU
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The synthesis of superparamagnetic nanoclusters is critical for ultra-sensitive magnetic resonance imaging (MRI). Herein, we describe the synthesis of water-soluble, biocompatible and superparamagnetic gadolinium-doped iron oxide nanoclusters (GdIO NCs) via a one-pot reaction by thermal decomposition of ferric oleate and gadolinium oleate precursors with alpha,omega-dicarboxyl poly(ethylene glycol) as a surfactant. The resulting water-dispersible GdIO NCs possess good stability and monodispersity with narrow size distribution, and exhibit superparamagnetic behaviors. We also explored the effect of gadolinium doping amounts on the magnetic properties and longitudinal (r(1)) and transverse relaxivity (r(2)) of the nanoclusters. In addition, the GdIO NCs can be functionalized with fluorescein isothiocyanate (FITC) while maintaining their magnetic properties and biocompatibility. The GdIO NCs and FITC conjugated NCs were preliminarily evaluated as MRI and fluorescent probes. The results show that the GdIO NCs provide an important nano-platform for theranostics with non-invasive MRI and optical monitoring capabilities.
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