Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 38, Issue 2, Pages 274-289Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X17744124
Keywords
Angiogenesis; brain recovery; brain trauma; regeneration and recovery; vascular biology
Categories
Funding
- NIH Program Project grant from National Institute of Neurological Disorders and Stroke [1P01NS082184]
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Recent data suggest that repairing the cerebral vasculature after traumatic brain injury (TBI) may help to improve functional recovery. The Wnt/beta-catenin signaling pathway promotes blood vessel formation during vascular development, but its role in vascular repair after TBI remains elusive. In this study, we examined how the cerebral vasculature responds to TBI and the role of Wnt/beta-catenin signaling in vascular repair. We induced a moderate controlled cortical impact in adult mice and performed vessel painting to visualize the vascular alterations in the brain. Brain tissue around the injury site was assessed for beta-catenin and vascular markers. A Wnt transgenic mouse line was utilized to evaluate Wnt gene expression. We report that TBI results in vascular loss followed by increases in vascular structure at seven days post injury (dpi). Immature, non-perfusing vessels were evident in the tissue around the injury site. beta-catenin protein expression was significantly reduced in the injury site at 7 dpi. However, there was an increase in beta-catenin expression in perilesional vessels at 1 and 7 dpi. Similarly, we found increased number of Wnt-GFP-positive vessels after TBI. Our findings suggest that Wnt/beta-catenin expression contributes to the vascular repair process after TBI.
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