Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 38, Issue 10, Pages 1828-1838Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X17734998
Keywords
Insulin resistance; exercise training; brain glucose metabolism; brain lipid metabolism; positron emission tomography
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Funding
- Academy of Finland
- University of Turku
- Turku University Hospital
- Abo Akademi University
- European Foundation for the Study of Diabetes
- Hospital District of Southwest Finland
- Orion Research Foundation
- Finnish Diabetes Foundation
- Emil Aaltonen Foundation
- Academy of Finland [251399, 251572, 256470, 281440, 283319]
- Ministry of Education of the State of Finland
- Paavo Nurmi Foundation
- Novo Nordisk Foundation
- Paulo Foundation
- Finnish Medical Foundation
- Turku University Foundation
- Finnish Cultural Foundation
- Academy of Finland (AKA) [283319, 281440, 283319, 251572, 281440, 251572] Funding Source: Academy of Finland (AKA)
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Brain insulin-stimulated glucose uptake (GU) is increased in obese and insulin resistant subjects but normalizes after weight loss along with improved whole-body insulin sensitivity. Our aim was to study whether short-term exercise training (moderate intensity continuous training (MICT) or sprint interval training (SIT)) alters substrates for brain energy metabolism in insulin resistance. Sedentary subjects (n=21, BMI 23.7-34.3kg/m(2), age 43-55y) with insulin resistance were randomized into MICT (n=11, intensity60% of VO2peak) or SIT (n=10, all-out) groups for a two-week training intervention. Brain GU during insulin stimulation and fasting brain free fatty acid uptake (FAU) was measured using PET. At baseline, brain GU was positively associated with the fasting insulin level and negatively with the whole-body insulin sensitivity. The whole-body insulin sensitivity improved with both training modes (20%, p=0.007), while only SIT led to an increase in aerobic capacity (5%, p=0.03). SIT also reduced insulin-stimulated brain GU both in global cortical grey matter uptake (12%, p=0.03) and in specific regions (p<0.05, all areas except the occipital cortex), whereas no changes were observed after MICT. Brain FAU remained unchanged after the training in both groups. These findings show that short-term SIT effectively decreases insulin-stimulated brain GU in sedentary subjects with insulin resistance.
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