Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 37, Issue 7, Pages 2314-2319Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X17700432
Keywords
Ischemic stroke; neural stem cells; preconditioning; cellular engineering; post-translational modifications
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Funding
- Intramural Research Program of the NINDS/NIH
- Wellcome Trust
- MRC
- NIH-OxCam Fellowship
- Wellcome Trust Research Training Fellowship [RRZA/057 RG79423]
- Gates-Cambridge Fellowship
- Medical Research Council [MC_PC_12009] Funding Source: researchfish
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Ischemic stroke continues to be a leading cause of morbidity and mortality throughout the world. To protect and/or repair the ischemic brain, a multitiered approach may be centered on neural stem cell (NSC) transplantation. Transplanted NSCs exert beneficial effects not only via structural replacement, but also via immunomodulatory and/or neurotrophic actions. Unfortunately, the clinical translation of such promising therapies remains elusive, in part due to their limited persistence/survivability within the hostile ischemic microenvironment. Herein, we discuss current approaches for the development of NSCs more amenable to survival within the ischemic brain as a tool for future cellular therapies in stroke.
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