Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 232, Issue 10, Pages 2776-2787Publisher
WILEY
DOI: 10.1002/jcp.25943
Keywords
diabetic nephropathy; dynamin-related protein 1; polydatin
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Funding
- Education Innovation Plan Program for Postgraduate in Guangxi Zhuang Autonomous Region [2011105981002D27]
- Natural Science Foundation of Guangxi Province [2012-181h-02-2012 GXNSFAA053106, 0832013Z]
- National Natural Science Foundation of China [81160533, 8150040851]
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Polydatin (PD), a resveratrol glycoside, has been shown to protect renal function in diabetic nephropathy (DN), but the underlying molecular mechanism remains unclear. This study demonstrates that PD stabilize the mitochondrial morphology and attenuate mitochondrial malfunction in both KKAy mice and in hyperglycemia (HG)-induced MPC5 cells. We use Western blot analysis to demonstrate that PD reversed podocyte apoptosis induced by HG via suppressing dynamin-related protein 1 (Drp1). This effect may depend on the ability of PD to inhibit the generation of cellular reactive oxygen species (ROS). In conclusion, we demonstrate thatPDmay be therapeutically useful in DN, and that, podocyte apoptosis induced byHGcan be reversed by PD through suppressing Drp1 expression.
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