Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 232, Issue 11, Pages 2957-2963Publisher
WILEY
DOI: 10.1002/jcp.25969
Keywords
bone; osteoarthritis; osteoblast
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Even if osteoarthritis pathogenesis is still poorly understood, numerous evidences suggest that osteoblasts dysregulation plays a key role in osteoarthritis pathogenesis. An abnormal expression of OPG and RANKL has been described in osteoarthritis osteoblasts, which is responsible for abnormal bone remodeling and decreased mineralization. Alterations in genes expression are involved in dysregulation of osteoblast function, bone remodeling, and mineralization, leading to osteoarthritis development. Moreover, osteoblasts produce numerous transcription factors, growth factors, and other proteic molecules which are involved in osteoarthritis pathogenesis.
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