Journal
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
Volume 30, Issue 1, Pages 4-10Publisher
OXFORD UNIV PRESS
DOI: 10.1093/icvts/ivz215
Keywords
Pulmonary carcinosarcoma; Chemotherapy; Nomogram; Age; Surgical treatment
Funding
- National Natural Science Foundation of China [81622001, 91642108, 81802260]
- Shanghai Science and Technology Committee [18140903900]
- Shanghai Rising-Star Program [19QA1407400]
- Shanghai Municipal Human Resources and Social Security Bureau [2017114]
- Fundamental Research Funds for the Central Universities [22120180510]
- Shanghai Pulmonary Hospital Fund for Excellent Young Scholars [fkyq1908]
- Shanghai Hospital Development Center [SHDC12017X03]
Ask authors/readers for more resources
OBJECTIVES: Pulmonary carcinosarcoma (PCS) is a rare neoplasm. This study explored the clinicopathological characteristics and survival outcomes of PCS. METHODS: The Surveillance, Epidemiology and End Results (SEER) database (1988-2014) was queried for PCS. Overall survival (OS) was evaluated by multivariable Cox regression and nomograms were constructed to predict 3-year OS for PCS. Prognostic performance was evaluated using concordance index and area under the curve analysis. In M0 surgically treated patients, interaction assessments were performed using likelihood ratio tests. Subgroup analysis was performed according to patient age. The clinical features of PCSs were further compared to other non-small-cell lung cancers (NSCLCs). RESULTS: Multivariable analysis identified age [hazard ratio (HR) 1.03, 95% confidence interval (CI) 1.01-1.04], surgery (HR 0.53, 95% CI 0.36-0.77) and chemotherapy (HR 0.51, 95% CI 0.36-0.73) as significantly associated with OS. The nomogram had a concordance index of 0.747 and an area under the curve of 0.803. The association between age and OS was stronger in those receiving pneumonectomy (P = 0.04 for interactions) compared to those that did not (HR 5.14, 95% CI 1.64-16.07), and was associated with a poorer outcome compared to lobectomy amongst the elderly (age >= 70 years). Patients with PCS were more likely to receive surgical treatment and had lower lymphatic metastasis compared to adenocarcinoma, squamous cell carcinoma and large cell carcinoma (all P < 0.05). CONCLUSIONS: PCS had unique clinical features compared to common types of NSCLCs in terms of lymphatic invasion and surgical treatment. Pneumonectomy was associated with poorer survival in elderly patients.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available