Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 118, Issue 10, Pages 3049-3054Publisher
WILEY
DOI: 10.1002/jcb.26005
Keywords
IMMUNOTHERAPY; CANCER IMMUNOLOGY; DRUG TARGETING; TUMOR MICROENVIRONMENT
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Funding
- Richard and Susan Smith Family Foundation
- Pew Charitable Trusts
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Targeting drugs to the tumor microenvironment has long been appreciated as a means of increasing local concentrations and decreasing systemic toxicities. How drug targeting might apply to immune-based therapies is less clear. In this review, we explain the immunology of cancer, with a focus on the principles of in situ vaccination. Certain types of therapies are more amenable to local versus systemic delivery; these include cytokines, adjuvants, radiation, and agents targeting tumor-resident cell populations. Several approaches for targeting the tumor microenvironment are under development. Nanoparticles, peptide or antibody-based delivery, and exploitation of cellular influx are all promising ways to delivery immune modulating compounds to tumors. (C) 2017 Wiley Periodicals, Inc.
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