Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 118, Issue 8, Pages 2454-2462Publisher
WILEY
DOI: 10.1002/jcb.25912
Keywords
CARDIAC REGENERATIVE THERAPY; STEM CELLS; SCAFFOLDS; TISSUE REGENERATION
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Cardiac regenerative therapy includes several techniques to repair and replace damaged tissues and organs using cells, biomaterials, molecules, or a combination of these factors. Generation of heart muscle is the most important challenge in this field, although it is well known that new advances in stem cell isolation and culture techniques in bioreactors and synthesis of bioactive materials contribute to the creation of cardiac tissue regeneration in vitro. Some investigations in stem cell biology shows that stem cells are an important source for regeneration of heart muscle cells and blood vessels and can thus clinically contribute to the regeneration of damaged heart tissue. The aim of this review was to explain the principles and challenges of myocardial tissue regeneration with an emphasis on stem cells and scaffolds. J. Cell. Biochem. 118: 2454-2462, 2017. (c) 2017 Wiley Periodicals, Inc.
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