Related references
Note: Only part of the references are listed.Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells
Sheela A. Abraham et al.
NATURE (2016)
Linsitinib (OSI-906) versus placebo for patients with locally advanced or metastatic adrenocortical carcinoma: a double-blind, randomised, phase 3 study
Martin Fassnacht et al.
LANCET ONCOLOGY (2015)
Phase I Study of Intermittent Oral Dosing of the Insulin-like Growth Factor-1 and Insulin Receptors Inhibitor OSI-906 in Patients With Advanced Solid Tumors
Robin L. Jones et al.
CLINICAL CANCER RESEARCH (2015)
A Phase I Study of Continuous Oral Dosing of OSI-906, a Dual Inhibitor of Insulin-Like Growth Factor-1 and Insulin Receptors, in Patients with Advanced Solid Tumors
Igor Puzanov et al.
CLINICAL CANCER RESEARCH (2015)
Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation
Leonard Girnita et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2014)
Pleiotropic antitumor effects of the pan-HDAC inhibitor ITF2357 against c-Myc-overexpressing human B-cell non-Hodgkin lymphomas
Roberta Zappasodi et al.
INTERNATIONAL JOURNAL OF CANCER (2014)
Insulin Receptor Substrate 1/2 ( IRS1/2) Regulates Wnt/β-Catenin Signaling through Blocking Autophagic Degradation of Dishevelled2
Yongtao Geng et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Wnt-Independent Role of β-Catenin in Thyroid Cell Proliferation and Differentiation
Ana Sastre-Perona et al.
MOLECULAR ENDOCRINOLOGY (2014)
Inhibition of type I insulin-like growth factor receptor tyrosine kinase by picropodophyllin induces apoptosis and cell cycle arrest in T lymphoblastic leukemia/lymphoma
Zhiwei Huang et al.
LEUKEMIA & LYMPHOMA (2014)
Stathmin 1 is involved in the highly proliferative phenotype of high-risk myelodysplastic syndromes and acute leukemia cells
Joao Agostinho Machado-Neto et al.
LEUKEMIA RESEARCH (2014)
Deregulated WNT signaling in childhood T-cell acute lymphoblastic leukemia
O. H. Ng et al.
BLOOD CANCER JOURNAL (2014)
The Skeletal Muscle Wnt Pathway May Modulate Insulin Resistance and Muscle Development in a Diet-Induced Obese Rat Model
Dan Zhou et al.
OBESITY (2012)
Cytogenetic and Molecular Predictors of Outcome in Acute Lymphocytic Leukemia: Recent Developments
Ilaria Iacobucci et al.
CURRENT HEMATOLOGIC MALIGNANCY REPORTS (2012)
High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling
Hind Medyouf et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
IRS1 Regulation by Wnt/β-Catenin Signaling and Varied Contribution of IRS1 to the Neoplastic Phenotype
Guido T. Bommer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-I receptor and insulin receptor
Mark J. Mulvihill et al.
FUTURE MEDICINAL CHEMISTRY (2009)
Nuclear insulin receptor substrate-1 activates promoters of cell cycle progression genes
A. Wu et al.
ONCOGENE (2008)
Insulin receptor substrate-1 is an important mediator of ovarian cancer cell growth suppression by all-trans retinoic acid
Sharada Ravikumar et al.
CANCER RESEARCH (2007)
A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor-dependent tumor growth in vivo
Qun-Sheng Ji et al.
MOLECULAR CANCER THERAPEUTICS (2007)
Expression of nuclear insulin receptor substrate 1 in breast cancer
Diego Sisci et al.
JOURNAL OF CLINICAL PATHOLOGY (2007)
Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2
Robert K. Dearth et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Functional significance of type 1 insulin-like growth factor-mediated nuclear translocation of the insulin receptor substrate-1 and β-catenin
J Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Mechanisms of disease: Acute lymphoblastic leukemia
C Pui et al.
NEW ENGLAND JOURNAL OF MEDICINE (2004)
Role of the IGF-I receptor in the regulation of cell-cell adhesion: Implications in cancer development and progression
L Mauro et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2003)
Insulin receptor substrate 1 translocation to the nucleus by the human JC virus T-antigen
A Lassak et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Casein kinase I phosphorylates and destabilizes the β-catenin degradation complex
ZH Gao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Insulin receptor substrate-1, p70S6K, and cell size in transformation and differentiation of hemopoietic cells
B Valentinis et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Cooperative transformation of 32D cells by the combined expression of IRS-1 and V-Ha-Ras
B Cristofanelli et al.
ONCOGENE (2000)