Journal
POLYMER CHEMISTRY
Volume 11, Issue 8, Pages 1445-1449Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9py01857c
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Funding
- National Science Foundation [CHE-1709820]
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Polypeptides with trigger-responsive helix-coil transition behaviours are interesting biomaterials due to their helix-specific assemblies and biomedical performances. Based on the pH-sensitive, conformationally switchable triazole polypeptides, we reported the manipulation of the helix-coil transition profile, which was determined by the combined molecular interactions of triazole and other side-chain functionalities. Specifically, the introduction of side-chain hydrophobic moieties or hydrogen bonding acceptors neutralized the helix-disrupting effect of side-chain triazoles, which altered the pH-responsive conformational transition profile of the polypeptides. These results inspired us to design new triazole polypeptides bearing dimethylamino side chains, which exhibited interesting helix-coil-helix transition behaviours as the pH decreased.
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