Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Volume 21, Issue 9, Pages 1687-1697Publisher
WILEY
DOI: 10.1111/jcmm.13112
Keywords
sepsis; neutrophil migration; neutrophil antimicrobial activity; neutrophil extracellular traps; signal pathway
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Funding
- National Natural Science Foundation of China [81571563, 81500432]
- Fundamental Research Funds for the Central Universities [021414380106]
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Sepsis remains a leading cause of death worldwide, despite advances in critical care, and understanding of the pathophysiology and treatment strategies. No specific therapy or drugs are available for sepsis. Neutrophils play a critical role in controlling infection under normal conditions, and it is suggested that their migration and antimicrobial activity are impaired during sepsis which contribute to the dysregulation of immune responses. Recent studies further demonstrated that interruption or reversal of the impaired migration and antimicrobial function of neutrophils improves the outcome of sepsis in animal models. In this review, we provide an overview of the associated mediators and signal pathways involved which govern the survival, migration and antimicrobial function of neutrophils in sepsis, and discuss the potential of neutrophils as a target to specifically diagnose and/or predict the outcome of sepsis.
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