Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Volume 21, Issue 12, Pages 3360-3371Publisher
WILEY
DOI: 10.1111/jcmm.13239
Keywords
PTTG3P; gastric cancer; prognosis; proliferation; invasion
Categories
Funding
- National Natural Science Foundation of China [81572254, 81472220, 81602269, 81602078, 81272299]
- Science and Technology Commission of the Shanghai Municipality [15495810300]
- Shanghai Hospital Development Centre Emerging Advanced Technology joint research project [HDC12014105]
- Shanghai Key Developing Disciplines [2015ZB0201]
- Shanghai Science and Technology Development Fund [15ZR1407400]
- Domestic Science and Technology Cooperation Project [14495800300]
- Hospital Foundation of the Fudan University Shanghai Cancer Center [YJ201504]
Ask authors/readers for more resources
Pseudogenes play a crucial role in cancer progression. However, the role of pituitary tumour-transforming 3, pseudogene (PTTG3P) in gastric cancer (GC) remains unknown. Here, we showed that PTTG3P expression was abnormally up-regulated in GC tissues compared with that in normal tissues both in our 198 cases of clinical samples and the cohort from The Cancer Genome Atlas (TCGA) database. High PTTG3P expression was correlated with increased tumour size and enhanced tumour invasiveness and served as an independent negative prognostic predictor. Moreover, up-regulation of PTTG3P in GC cells stimulated cell proliferation, migration and invasion both in vitro in cell experiments and in vivo in nude mouse models, and the pseudogene functioned independently of its parent genes. Overall, these results reveal that PTTG3P is a novel prognostic biomarker with independent oncogenic functions in GC.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available