Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Volume 21, Issue 9, Pages 1803-1814Publisher
WILEY
DOI: 10.1111/jcmm.13101
Keywords
heart failure; LncRNA; NRON; MHRT; plasma
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Funding
- Funds for Creative Research Groups of the National Natural Science Foundation of China [81421063]
- Key Project of National Science Foundation of China [81230081, 81130088]
- National Basic Research Program of China (973 program) [2013CB531104]
- Major Program of National Natural Science Foundation of China [81530010]
- Natural Science Foundation of China [81170219, 81371211, 81570357]
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This study sought to evaluate the potential of circulating long non-coding RNAs (lncRNAs) as biomarkers for heart failure (HF). We measured the circulating levels of 13 individual lncRNAs which are known to be relevant to cardiovascular disease in the plasma samples from 72 HF patients and 60 non-HF control participants using real-time reverse transcription-polymerase chain reaction (real-time RT-PCR) methods. We found that out of the 13 lncRNAs tested, non-coding repressor of NFAT (NRON) and myosin heavy-chain-associated RNA transcripts (MHRT) had significantly higher plasma levels in HF than in non-HF subjects: 3.17 +/- 0.30 versus 1.0 +/- 0.07 for NRON (P<0.0001) and 1.66 +/- 0.14 versus 1.0 +/- 0.12 for MHRT (P<0.0001). The area under the ROC curve was 0.865 for NRON and 0.702 for MHRT. Univariate and multivariate analyses identified NRON and MHRT as independent predictors for HF. Spearman's rank correlation analysis showed that NRON was negatively correlated with HDL and positively correlated with LDH, whereas MHRT was positively correlated with AST and LDH. Hence, elevation of circulating NRON and MHRT predicts HF and may be considered as novel biomarkers of HF.
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