Journal
JOURNAL OF CELL SCIENCE
Volume 130, Issue 17, Pages 2781-2788Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jcs.203679
Keywords
Autophagy; Chaperone; Proteostasis; Ubiquitin; Hippo signalling; mTOR regulation
Categories
Funding
- Deutsche Forschungsgemeinschaft [DFG SFB 645 TPC6, FOR 1352 P10, HO 1518/9-1]
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Cellular and organismal survival depend on the ability to maintain the proteome, even under conditions that threaten protein integrity. BCL2-associated athanogene 3 (BAG3) is essential for protein homeostasis (proteostasis) in stressed cells. Owing to its multidomain structure, it engages in diverse processes that are crucial for proteome maintenance. BAG3 promotes the activity of molecular chaperones, sequesters and concentrates misfolded proteins, initiates autophagic disposal, and balances transcription, translation and degradation. In this Cell Science at a Glance article and the accompanying poster, we discuss the functions of this multi-functional proteostasis tool with a focus on mechanical stress protection and describe the importance of BAG3 for human physiology and pathophysiology.
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