Journal
JOURNAL OF CELL BIOLOGY
Volume 216, Issue 11, Pages 3463-3470Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201609114
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Funding
- Fundacao para a Ciencia e a Tecnologia
- Programa Operacional Potencial Humano/Fundo Social Europeu [SFRH/BD/75004/2010]
- National Institutes of Health [R01-GM053959]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/75004/2010] Funding Source: FCT
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The size of nearly all cells is modulated by nutrients. Thus, cells growing in poor nutrients can be nearly half the size of cells in rich nutrients. In budding yeast, cell size is thought to be controlled almost entirely by a mechanism that delays cell cycle entry until sufficient growth has occurred in G1 phase. Here, we show that most growth of a new daughter cell occurs in mitosis. When the rate of growth is slowed by poor nutrients, the duration of mitosis is increased, which suggests that cells compensate for slow growth in mitosis by increasing the duration of growth. The amount of growth required to complete mitosis is reduced in poor nutrients, leading to a large reduction in cell size. Together, these observations suggest that mechanisms that control the extent of growth in mitosis play a major role in cell size control in budding yeast.
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