Journal
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
Volume 69, Issue 6, Pages 335-342Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/FJC.0000000000000465
Keywords
Poldip2; extracellular matrix; focal adhesions; DNA repair; redox signaling
Funding
- NIH [HL038206, HL095070]
- FAPESP
Ask authors/readers for more resources
Polymerase delta-interacting protein 2 (Poldip2) is a multifunctional protein originally described as a binding partner of the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen. In addition to its role in DNA replication and damage repair, Poldip2 has been implicated in mitochondrial function, extracellular matrix regulation, cell cycle progression, focal adhesion turnover, and cell migration. However, Poldip2 functions are incompletely understood. In this review, we discuss recent literature on Poldip2 tissue distribution, subcellular localization, and function. We also address the putative function of Poldip2 in cardiovascular disease, neurodegenerative conditions and in renal pathophysiology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available