Journal
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
Volume 52, Issue 2, Pages 150-159Publisher
SCIENCE PRESS
DOI: 10.1093/abbs/gmz151
Keywords
gastric cancer; miR-223-3p; Arid1a; proliferation and invasion
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Funding
- Natural Science Research Project of College and Universities in Anhui Province [KJ2017A262]
- Funding of the 'Peak' Training Program for Scientific Research of Yijishan Hospital, Wannan, Medical College [GF2019G11]
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Accumulating evidence has indicated that microRNAs can regulate downstream signaling pathways and play an important role in various tumors. In this study, we found that miR-223-3p was differentially expressed in 40 paired gastric cancer tissues and adjacent tissues and that miR-223-3p was positively correlated with tumor invasion depth and lymph node metastasis. Luciferase reporter assay confirmed that Arid1a was the target gene of miR-223-3p. Functional assays showed that miR-223-3p promoted the proliferation and invasion of gastric cancer cells by regulating the expression of Arid1a. We also confirmed that miR-223-3p regulated the growth of gastric cancer cells in vivo, while an antagomir against miR-223-3p significantly inhibited tumor growth. In conclusion, our results demonstrated that miR-223-3p inhibits gastric cancer cell progression by decreasing the expression of Arid1a. Therefore, miR-223-3p may act as a potential therapeutic target for patients with gastric cancer.
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